Figure 3

Extent of infarcts and behavioral recovery. (a,e) Axial T2-weighted MR images of the brains of Monkeys 1 (a) and 2 (e), showing the locations of the infarcts 1 month after endothelin-1 injection. The yellow squares indicate the areas shown in (b,f). (b,f) Higher-magnification MR images around the infarcts. The violet dotted lines indicate the anterior two-thirds of the posterior limb of the internal capsule, which contains fibers of the corticospinal tract. The magenta solid lines indicate the hypointense infarct core; T2-hyperintense cystic lesions were also found in Monkey 2. (c,g) Nissl-stained coronal sections made from the anterior two-thirds of the posterior limb of the internal capsule after the completion of the fNIRS measurements and pharmacological inactivation experiment. The area bordered by the violet dotted lines indicates the internal capsule (IC). The magenta solid lines indicate the lesioned area, which is defined as the area of a dense concentration of small cells (5–10 μm in diameter), which presumably include both glial cells and blood cells. The images were acquired with a microscope (BX60, Olympus, Tokyo, Japan) equipped with a 3CCD color video camera (DHC-950, Sony, Tokyo, Japan) and digitized with an image analysis system (version 2019.1.1, Stereo Investigator, MBF Bioscience Inc., Williston, VT, USA. URL https://www.mbfbioscience.com/stereo-investigator.). Cd, caudate nucleus; Put, putamen. Scale bar = 1 mm. (d,h) Time course of changes in the success rates of retrieval (gray) and precision grip (orange), as evaluated with the vertical slit task. The mean and standard deviation before infarction and every 20 days after infarction are indicated.