Figure 6

Effects of inactivating PMv on the performance of dexterous hand movements. (a–c) Muscimol injections into the ipsilesional (left) PMv of Monkey 1 resulted in a significant deficit of the right hand in performing the Klüver board task with well diameters of 11 or 10 mm, but not 20 mm. (d,e) Muscimol injections into the contralesional (right) PMv of Monkey 2 resulted in a significant deficit of the right hand in performing the vertical slit task (d), whereas muscimol injections into the ipsilesional (left) PMv did not significantly change performance for either hand (e). *p < 0.05, **p < 0.01, Fisher’s exact test. (f) Representative Nissl-stained section showing brain microinjection sites in the contralesional PMv of Monkey 2. The dotted lines with arrows indicate the estimated spread of muscimol. The muscimol injection was also confirmed in the ipsilesional PMv of both monkeys in the same manner. The image was acquired with a microscope (BX60, Olympus, Tokyo, Japan) equipped with a 3CCD color video camera (DHC-950, Sony, Tokyo, Japan) and digitized with an image analysis system (version 2019.1.1, Stereo Investigator, MBF Bioscience Inc., Williston, VT, USA. URL https://www.mbfbioscience.com/stereo-investigator.). Scale bar = 2 mm.