Figure 7
From: Chronic Intermittent Hypoxia Triggers a Senescence-like Phenotype in Human White Preadipocytes
Intermittent hypoxia (IH)-induced senescence is attenuated by treatment with aspirin, atorvastatin, and renin-angiotensin system targeted drugs. IH mediated increased prevalence of SA-β-gal positive cells was attenuated by concomitant treatment with aspirin, atorvastatin, angiotensin II type-1 receptor antagonist (losartan), and angiotensin converting enzyme inhibitor (captopril) (a). Representative images of SA-β-gal staining with green marks indicating senescent cells (b). Data are presented as mean ± SEM, *P < 0.05 determined by one-tailed paired t-test (n = 3–5 independent experiments) as compared to IH. NO: normoxia; AngII: angiotensinII.
