Figure 3

Jumping strategies for updating the copy number boundaries in the RJMCMC algorithm. (a) Merge and split, (b) merge (double merge) and trifid, and (c) boundary change. Each rectangular box indicates a window, and the texture indicates the state of the CN. Continuous windows with the same state are combined into a CN region. For example, in a the slash and argyle CN regions in the left graph are combined into a single region through the merge strategy. One of the original states is assigned to the new region shown in the right graph. Conversely, the slash or argyle region on the right graph is divided into two regions through the split strategy on the left graph.