Figure 1

Study protocol. Once the transplant performed, mice were followed by imaging and then randomized into 2 groups: sunitinib or control. Imaging sessions included 7 T MRI imaging for accurate estimation of tumor volume, then ultrasound molecular imaging acquisitions at baseline and at 7, 14 and 28 days after initiation of treatment and a final 7TMRI for accurate estimation of the final volume. For each examination, non-targeted and targeted contrast agents for both markers (FSHR and VEGFR-1) were injected.