Figure 2 | Scientific Reports

Figure 2

From: Ultrasound Molecular Imaging of Renal Cell Carcinoma: VEGFR targeted therapy monitored with VEGFR1 and FSHR targeted microbubbles

Figure 2

Examples of molecular imaging acquisitions on the same mouse. The ultrasound image is given for each contrast agent CA (non-targeted, targeted FSHR and VEGFR1), with the signal intensity measured within the tumor. The red band (green dash under the echo image) represents the destruction of the microbubbles (burst), with the signal measured before (10 minutes after injection of the CA) and the signal measured during replenishment. During the 10 minutes period following the injection of CA, the microbubbles attach to the receptors. Then, the microbubbles are destroyed before visualizing the reperfusion. The differential targeted enhancement DTE is calculated and corresponds to the difference between the signal at 10 minutes and the signal after replenishment. The quantity is proportional to the quantity of biomarkers in the region of interest.

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