Table 1 Estimated causal effect of BMI on diabetes from Mendelian randomization.

From: Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes

MR method

Estimate

95% CI

p-value

MR-Egger

1.058

1.015 1.102

9.07 × 10−3

(Intercept)

−0.001*

−0.002 0.001

0.335

Weighted median

1.051

1.043 1.061

8.18 × 10−30

Inverse variance weighted

1.038

1.021 1.057

1.76 × 10−5

MR-RAPS

1.048

1.042 1.054

8.27 × 10−51

  1. “Estimate” represents the estimated odds ratio, i.e., change in odds of diabetes per 1-SD (or 4.5 kg/m2) increase in BMI. *Estimate of “Intercept” in MR-Egger represents the estimated coefficient of horizontal pleiotropy. MR: Mendelian randomization, CI: confidence interval.
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