Figure 1 | Scientific Reports

Figure 1

From: Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer’s disease risk

Figure 1

Model of ACKR2-V41A does not predict a change in protein folding and predicts a minor decrease in hydrophilicity. There is no dramatic difference in predicted protein folding and a minor decrease in hydrophilicity between ACKR2-WT and ACKR2-V41A. (A) Side by side ribbon view of ACKR2-WT (blue and green) and ACKR2-V41A (gold and red) protein models. (B) Overlay of ACKR2-WT and ACKR2-V41A ribbon models highlighting the folding at amino acid position 41 (WT is green and V41A is red). (C) Side by side ribbon structure of amino acid position 39–43 for ACKR2-WT and ACKR2-V41A (WT is green and V41A is red) (D) View of hydrophobic (red) and hydrophilic (blue) amino acids at amino acid positions 39–43 for the ACKR2-WT (left) and ACKR2-V41A (right) chemokine binding site. Amino acid 41 is shown in the middle right of both models.

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