Figure 4

C. albicans molecular pathways analyses; The genes in the ergosterol biosynthesis pathway that are affected by fluconazole, C12AHL or C12AHL + fluconazole exposure. Comparisons denoted with * are significant (adjusted p-value < 1e⁻⁵). ERG1: Squalene epoxidase, ERG2: C-8 sterol isomerase, ERG3: C-5 sterol desaturase, ERG4: sterol C-24 reductase, ERG5: C-22 sterol desaturase, ERG6: Delta (24)-sterol C-methyltransferase, ERG7: 2,3-epoxysqualene-lanosterol cyclase (lanosterol synthase), ERG8: phosphomevalonate kinase, ERG9: farnesyl-diphosphate farnesyl transferase (squalene synthase), ERG10: Acetyl-CoA acetyltransferase, ERG11: Lanosterol 14-alpha-demethylase, ERG12: mevalonate kinase, ERG13: 3-hydroxy-3-methylglutaryl coenzyme A synthase, ERG20: farnesyl pyrophosphate synthetase, ERG24: C-14 sterol reductase, ERG25: C-4 methyl sterol oxidase, ERG26: C-3 sterol dehydrogenase, ERG27: 3-Keto sterol reductase, HMG1: HMG-CoA reductase, IDI1: isopentenyl-diphosphate delta-isomerase, and MVD: Mevalonate diphosphate decarboxylase.