Table 3 Gene expression data; The C. albicans genes that were significantly affected by both C12AHL only and C12AHL + fluconazole exposure compared to untreated controls [(C12AHL vs Control) vs (C12AHL + fluconazole vs Control)]. Genes highlighted in blue are known to be associated with antifungal resistance/sensitivity. (http://www.candidagenome.org/).

C3_03460C_A

Protein of unknown function

3.45

3.54E-23

3.19

4.58E-20

IFD6

Aldo-keto reductase

3.00

2.14E-21

3.02

1.11E-21

UGT51C1

UDP-glucose:sterol glucosyltransferase

2.20

1.95E-19

2.38

1.45E-22

CRZ2

C2H2 transcription factor

2.30

2.41E-14

2.51

2.86E-17

ATX1

Putative cytosolic copper metallochaperone

2.74

3.92E-14

2.75

2.42E-14

ALK2

N-Alkane inducible cytochrome P450

1.93

2.75E-13

1.63

1.09E-09

NRG1

Transcription factor/repressor

1.95

9.01E-13

2.18

4.02E-16

C1_01510W_A

Protein of unknown function

2.41

1.41E-11

2.46

2.65E-12

CDR4

Putative ABC transporter superfamily

1.76

1.68E-11

1.70

6.09E-11

YOR1

ABC-type plasma membrane transporter

1.35

3.45E-11

1.41

2.33E-12

WOR4

Predicted C2H2 zinc finger protein

2.08

6.53E-11

2.40

1.18E-14

ADA2

Zinc finger and homeodomain transcriptional coactivator

1.51

8.98E-11

1.67

2.43E-13

C6_02100W_A

Secreted protein

−3.73

1.15E-10

−3.54

9.31E-10

OPT3

Oligopeptide transporter

2.16

1.39E-10

2.15

1.60E-10

SRR1

Two-component system response regulator

2.15

1.81E-10

2.24

1.98E-11

C7_04090C_A

Predicted mitochondrial cardiolipin-specific phospholipase

2.33

2.33E-10

2.35

1.59E-10

C1_09210C_A

Putative transporter

1.72

2.42E-10

1.47

8.96E-08

C3_05450C_A

Protein of unknown function

2.38

4.54E-10

2.53

2.17E-11

ZCF1

Zn(II)2Cys6 transcription factor

1.43

6.29E-10

1.59

2.33E-12

RFG1

HMG domain transcriptional repressor

1.81

7.32E-10

1.94

3.12E-11

MOH1

Ortholog of S. cerevisiae Moh1

1.61

2.14E-09

1.68

2.64E-10

CR_09100C_A

Aldo-keto reductase

2.30

4.70E-09

2.35

1.36E-09

FBA1

Fructose-bisphosphate aldolase

−1.79

5.31E-09

−1.64

8.92E-08

EFG1

bHLH transcription factor

1.88

7.64E-09

1.97

9.31E-10

CR_10230W_A

Ortholog(s) have histone acetyltransferase activity

1.07

8.15E-09

1.36

2.94E-14

HSP78

Heat-shock protein

2.23

1.33E-08

2.22

1.27E-08

RPN4

C2H2 transcription factor

1.34

1.56E-08

1.40

3.13E-09

SNQ2

Protein similar to S. cerevisiae Snq2p transporter

1.74

1.56E-08

1.55

6.73E-07

CR_06140W_A

Protein of unknown function

1.96

1.56E-08

1.98

1.08E-08

C7_00770W_A

Protein of unknown function

2.19

1.73E-08

1.81

6.81E-06

HSP104

Heat-shock protein

2.54

1.83E-08

2.47

3.99E-08

GOR1

Ortholog(s) have glyoxylate reductase activity

2.16

1.86E-08

2.00

2.37E-07

IFR2

Zinc-binding dehydrogenase

−1.82

4.01E-08

−1.78

8.07E-08

AAF1

Possible regulatory protein

2.13

5.63E-08

2.18

2.21E-08

YIM1

Protein similar to protease of mitochondrial inner membrane

1.95

6.00E-08

2.00

2.04E-08

PHHB

Putative 4a-hydroxytetrahydrobiopterin dehydratase

−1.78

1.04E-07

−1.72

2.87E-07

ERO1

Ortholog of S. cerevisiae Ero1

1.91

1.20E-07

2.00

1.82E-08

MNN42

Protein of unknown function

1.25

1.48E-07

1.43

6.88E-10

HAL9

Putative Zn(II)2Cys6 transcription factor

1.35

2.48E-07

1.40

5.22E-08

ADH3

Putative NAD-dependent (R,R)-butanediol dehydrogenase

3.05

2.81E-07

3.25

2.36E-08

INO2

Transcriptional activator

1.76

3.13E-07

1.92

1.24E-08

CSH1

Aldo-keto reductase

1.91

3.78E-07

1.87

5.61E-07

C6_00290W_A

Protein of unknown function

1.54

4.63E-07

1.67

2.04E-08

GRP2

Methylglyoxal reductase

2.50

4.86E-07

2.62

8.07E-08

ISA1

Putative mitochondrial iron-sulfur protein

1.39

7.93E-07

1.55

1.62E-08

RME1

Zinc finger protein

1.98

9.00E-07

2.17

3.28E-08

C1_04010C_A

Protein with a NADP-dependent oxidoreductase domain

1.57

1.54E-06

1.68

1.47E-07

GAL102

UDP-glucose 4,6-dehydratase

1.85

1.54E-06

2.05

3.84E-08

C5_04030W_A

Protein of unknown function

1.85

2.15E-06

2.08

3.99E-08

C4_03020W_A

Putative mitochondrial GTPase

0.98

2.64E-06

1.18

4.87E-09

ALS7

ALS family protein

0.95

2.83E-06

1.12

1.07E-08

MNN12

Predicted alpha-1,3-mannosyltransferase

−1.90

2.89E-06

−1.93

1.55E-06

C3_02630C_A

Protein of unknown function

1.20

3.87E-06

1.42

1.29E-08

SIS1

Putative Type II HSP40 co-chaperone

1.98

3.87E-06

1.94

5.25E-06

LPG20

Aldo-keto reductase family protein

1.71

3.87E-06

1.65

8.38E-06

HSP90

Essential chaperone

1.71

3.87E-06

1.85

2.86E-07

MHP1

Protein similar to S. cerevisiae Mhp1p

1.10

3.93E-06

1.09

4.69E-06

C3_00360W_A

Protein of unknown function

1.43

4.78E-06

1.88

2.21E-10

C1_03990W_A

Ortholog(s) have proteasome binding activity

1.64

6.48E-06

1.95

2.07E-08

CR_06960W_A

Ortholog(s) have ATP binding, DNA replication origin binding activity

1.29

6.48E-06

1.35

1.73E-06

C1_01130W_A

Putative ubiquitin ligase complex component

1.06

7.23E-06

1.09

2.80E-06

RGS2

Protein of RGS superfamily

1.17

7.97E-06

1.39

3.28E-08

CR_07480W_A

Predicted auxin family transmembrane transporter

1.02

9.33E-06

1.22

2.41E-08

C4_02740W_A

Protein of unknown function

1.48

9.33E-06

1.54

2.80E-06