Figure 3

Representative histology and immunohistochemistry of IOPN and IPMN/IPNB. IOPN of pancreas, pure type (a–d), IOPN of bile duct, pure type (e–h), IOPN of pancreas, combined type (i–l), IPMN, intestinal subtype (m,n), IPMN, gastric subtype (o,p), and IPNB, intestinal subtype (q,r). Immunohistochemistry for FST (b, f, j, n, p, r), for mitochondria (c, g, k). Immunohistochemistry for Cleaved Caspase 3 (CC3) is shown in the inset of d, l, m, q. Intense/weak/negative staining for FST was seen in b, f /j / n, p, r. Note that the IOPN area is weakly positive for FST (white arrowheads), whereas gastric IPMN area is negative for FST (black arrowheads) in the combined type. Apoptotic figures were seen sparsely scattered/in aggregates in d, h, o/l, m, q (Arrows).