Figure 2 | Scientific Reports

Figure 2

From: Chronic Sympathetic Hyperactivity Triggers Electrophysiological Remodeling and Disrupts Excitation-Contraction Coupling in Heart

Figure 2

Reduced LCC currents contribute to impaired cellular contractility in ARDKO VCMs. Panel (A) shows representative LCC currents records from WT (black) and ARDKO (red) VCMs. ARDKO had reduced LCC current (B), with no significant modulation of stationary voltage-dependency for activation (C) and inactivation (D) of the LCC. (WT n = 25 cells/4 hearts; ARDKO n = 29 cells/4 hearts). *p < 0.05 when compared to WT.

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