Table 1 Association analysis between DEGs responsive to BPA in the offspring hippocampus and top-ranked genes associated with Alzheimer’s disease identified by AlzBase.

From: Prenatal exposure to bisphenol A alters the transcriptome-interactome profiles of genes associated with Alzheimer’s disease in the offspring hippocampus

List of DEGs from Rat Hippocampus

#DEGs

Number of Overlapping Genes with AlzBase

Hypergeometric P-value

List of Overlapping Genes with Alzbase

Both Sexes

4,525

24

0.925

ACACB, AEBP1, BSCL2, DYNC1I1, FIBP, FSTL1, GABRA1, GFAP, GOT1, GPI, HBB, ITPKB, MAL2, NELL2, NRSN1, NSF, PCP4, PGK1, RCAN2, SCG2, SCG5, SLC14A1, SNX10, TJP2

Male

1,633

20

0.011

AEBP1, CCK, CRYM, FOXO1, GPRASP1, HBB, INA, ITPKB, KIFAP3, MAL2, MLLT11, NRSN1, NSF, PGK1, RIT2, RPH3A, SASH1, SNAP25, SNX10, TXNIP

Female

2,780

31

0.005

ABCA1, AEBP1, AMPH, ATP1A1, BCL6, CCK, CDK5, DYNC1I1, EMP1, FOXO1, FSTL1, GFAP, HBB, ITPKB, MAL2, MLLT11, NCALD, NELL2, NME1, NSF, NUPR1, PCP4, SCG2, SNAP25, SNX10, STMN2, SVOP, TGFBR3, TMEM14A, TRIP10, UCHL1

  1. Hypergeometric distribution analyses were used to analyze associations between significant DEGs responsive to BPA and top-ranked Alzheimer’s candidate genes obtained from AlzBase. Statistically significant associations were determined by hypergeometric distribution analysis. P-value < 0.05 is considered as significant.
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