Table 2 Gene ontology analysis of DEGs in the hippocampus of rats prenatally exposed to BPA.
Categories | P-value | # DEGs |
|---|---|---|
Both Sexes | ||
Canonical Pathways | ||
Calcium Signaling | 3.98E-05 | 63 |
Protein Kinase A Signaling | 3.98E-04 | 103 |
AMPK Signaling | 1.05E-03 | 59 |
NRF2-mediated Oxidative Stress Response | 1.51E-03 | 53 |
Synaptogenesis Signaling Pathway | 3.31E-03 | 79 |
PI3K/AKT Signaling | 3.47E-03 | 48 |
NF-κB Activation | 3.98E-03 | 26 |
Apoptosis Signaling | 4.47E-03 | 30 |
Diseases/Disorders | ||
Cancer | 9.74E-129 - 9.16E-06 | 3,984 |
Endocrine System Disorders | 2.58E-113 - 6.62E-06 | 3,427 |
Gastrointestinal Disease | 1.85E-109 - 6.12E-06 | 3,601 |
Immunological Disease | 5.56E-16 - 9.16E-06 | 1,414 |
Neurological Disease | 8.77E-14 - 8.66E-06 | 1,360 |
Biological Functions | ||
Lipid Metabolism | 5.31E-13 - 8.56E-06 | 602 |
Nervous System Development and Function | 3.64E-10 - 5.62E-06 | 744 |
Connective Tissue Development and Function | 4.38E-10 - 4.16E-06 | 519 |
Inflammatory Response | 2.37E-08 - 3.67E-06 | 691 |
Free Radical Scavenging | 2.03E-06 - 5.61E-06 | 188 |
Predicted Upstream Regulators | ||
Levodopa | 3.27E-12 | 206 |
TP53 | 8.85E-10 | 480 |
HNF4A | 4.04E-09 | 527 |
TGFB1 | 6.09E-09 | 455 |
beta-estradiol | 2.88E-07 | 492 |
Male | ||
Canonical Pathways | ||
Synaptogenesis Signaling Pathway | 3.16E-07 | 47 |
Glutamate Receptor Signaling | 2.29E-05 | 14 |
Circadian Rhythm Signaling | 1.45E-03 | 8 |
IL-15 Production | 1.51E-03 | 18 |
Axonal Guidance Signaling | 1.62E-03 | 51 |
Amyotrophic Lateral Sclerosis Signaling | 2.51E-03 | 15 |
Huntington’s Disease Signaling | 3.55E-03 | 28 |
GABA Receptor Signaling | 5.37E-03 | 14 |
Diseases/Disorders | ||
Cancer | 6.33E-114 - 8.47E-10 | 2,468 |
Endocrine System Disorders | 6.33E-114 - 7.38E-10 | 2,160 |
Gastrointestinal Disease | 2.76E-106 - 6.03E-10 | 2,273 |
Reproductive System Disease | 3.83E-67 - 7.88E-10 | 1,737 |
Neurological Disease | 1.89E-31 - 5.17E-10 | 1,094 |
Biological Functions | ||
Nervous System Development and Function | 2.76E-41 - 7.39E-10 | 800 |
Cellular Growth and Proliferation | 6.39E-40 - 5.77E-10 | 772 |
Cell Death and Survival | 8.03E-31 - 4.75E-11 | 920 |
Embryonic Development | 5.48E-28 - 7.39E-10 | 713 |
Behavior | 3.18E-20 - 3.16E-11 | 231 |
Predicted Upstream Regulators | ||
MAPT | 1.28E-11 | 66 |
HTT | 1.09E-07 | 89 |
BDNF | 2.79E-07 | 49 |
APP | 2.01E-06 | 105 |
LMNB1 | 3.23E-06 | 15 |
Female | ||
Canonical Pathways | ||
Synaptogenesis Signaling Pathway | 1.00E-12 | 82 |
Reelin Signaling in Neurons | 4.27E-09 | 40 |
Calcium Signaling | 6.03E-08 | 52 |
Axonal Guidance Signaling | 9.33E-08 | 97 |
AMPK Signaling | 9.77E-07 | 50 |
Glutamate Receptor Signaling | 3.80E-06 | 20 |
Amyloid Processing | 7.59E-06 | 18 |
Synaptic Long Term Potentiation | 7.24E-05 | 31 |
Diseases/Disorders | ||
Cancer | 6.33E-114 - 8.47E-10 | 2,468 |
Endocrine System Disorders | 6.33E-114 - 7.38E-10 | 2,160 |
Gastrointestinal Disease | 2.76E-106 - 6.03E-10 | 2,273 |
Reproductive System Disease | 3.83E-67 - 7.88E-10 | 1,737 |
Neurological Disease | 1.89E-31 - 5.17E-10 | 1,094 |
Biological Functions | ||
Nervous System Development and Function | 2.76E-41 - 7.39E-10 | 800 |
Cellular Growth and Proliferation | 6.39E-40 - 5.77E-10 | 772 |
Cell Death and Survival | 8.03E-31 - 4.75E-11 | 920 |
Embryonic Development | 5.48E-28 - 7.39E-10 | 713 |
Behavior | 3.18E-20 - 3.16E-11 | 231 |
Predicted Upstream Regulators | ||
TGFB1 | 5.31E-23 | 364 |
beta-estradiol | 1.03E-18 | 382 |
TP53 | 8.38E-15 | 345 |
APP | 1.58E-14 | 195 |
ERBB2 | 2.85E-13 | 163 |
