Figure 2 | Scientific Reports

Figure 2

From: Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis

Figure 2

Increased pS6RP expression in parietal epithelial cells in sclerotic glomeruli. (A, C, E) Representative images of a morphological normal glomerulus of an anti-Thy1.1 mouse 4 days after disease induction. SSeCKS (green, A, E), pS6RP (red, C, E) and synaptopodin (violet, E) expression is shown. pS6RP expression was observed in some SSeCKS positive cells (arrow) and in some synaptopodin positive podocytes (arrowhead) and outside of the glomerulus (asterisk). (B, D, F) Representative images of a sclerotic glomerulus of an anti- Thy1.1 mouse 4 days after disease induction. In sclerotic glomeruli an increased pS6RP expression in SSeCKS positive PECs was observed (arrows). pS6RP expression could also be detected outside of the glomerulus (asterisk).

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