Figure 4
From: Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
Synaptc receptor affinity is maintained for at least 5 days at 2 °C and 2 days at 21 °C. (a) Ion currents elicited by different concentrations of GABA and kainate in two oocytes microtransplanted with rat synaptic receptors. Only oocytes with full dose responses and fits with p values <0.05 were included in the analysis. (b–d) Concentration response curves for kainate and GABA (each point was calculated as the mean of 2–3 microtransplanted oocytes; see supplementary Table 4). Curve fitting was done using the Hill equation Icurrent = 100/[1 + 10^((LogEC50-[agonist])*HillSlope)]. (c–e) EC50 (mean + SEM) was calculated for each dose-response curve. 21 °C/120 hrs had no current responses. All the groups were fit with a linear regression equation.
