Table 1 Pearson correlation coefficient of facultative pathogenic bacteria and antibiotic resistance genes in treated wastewater with no influence of hospital wastewater (WWTP cluster C) and with hospital-influenced wastewater (WWTP cluster H).

	sulfonamid resistance (sul1)	erythromycin resistance (ermB)	β-lactam resistance (bla_TEM)	tetracycline resistance (tetM)	cephalosporine resistance (bla_CTX-M32)	carbapenem resistance (bla_OXA48)	cephalosporine resistance (bla_CTX-M15)	ampicillin resistance (bla_CMY-2)	methicillin resistance (mecA)	carbapenem resistance (bla_NDM-1)	colistin resistance (mcr-1)	vancomycin resistance (vanA)	mobile genetic element (intI1)
WWTP effluents of cluster C
E. coli	0.701	0.859	-0.098	0.889	0.783	0.431	0.971	0.755	0.484	0.001	0.538	0.233	0.211
K. pneumoniae	0.365	0.443	0.018	0.735	0.195	0.659	0.717	0.460	0.206	0.052	0.252	0.164	0.333
enterococci	0.356	0.342	−0.114	0.616	0.174	0.374	0.538	0.308	0.245	0.256	0.151	0.157	0.179
A. baumannii	0.649	0.730	−0.001	0.734	0.499	0.461	0.811	0.622	0.433	0.112	0.455	0.459	0.178
P. aeruginosa	0.615	0.695	−0.152	0.861	0.575	0.531	0.600	0.600	0.372	0.024	0.496	0.573	0.464
WWTP effluents of cluster H
E. coli	0.152	0.216	−0.080	0.081	0.203	0,138	0.267	0.051	−0.026	0.395	0.161	−0.058	0.067
K. pneumoniae	0.046	0.702	0.118	0.415	0.674	0,148	0.775	0.403	0.128	0.766	0.123	0.271	0.218
enterococci	0.085	0.705	0.195	0.298	0.719	0,364	0.825	0.321	0.365	0.783	0.143	0.718	0.601
A. baumannii	0.168	0.598	0.027	0.214	0.479	0,549	0.536	0.348	0.588	0.723	0.352	0.027	0.667
P. aeruginosa	0.167	0.426	−0.098	0.206	0.358	0,679	0.557	0.279	0.623	0.815	0.263	−0.077	0.896

A Pearson correlation coefficient >0.1 corresponds to a low/weak correlation, a coefficient >0.3 corresponds to a medium/moderate correlation, and a coefficient >0.5 (bold) corresponds to a strong/significant correlation between two parameters^38,39. A Pearson correlation coefficient <0 corresponds to a counter/inverse correlation.

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