Table 1 Association of HOXB13 p.G84E with breast cancer risk in women of European descent.
From: Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk
N Controls | N Cases | CAF (%) Controls | CAF (%) Cases | OR (95% CI)* | P-value* | |
|---|---|---|---|---|---|---|
Overall analysis | ||||||
Europeans | 44,298 | 54,731 | 0.510 | 0.471 | 1.03 (0.86–1.24) | 0.74 |
Subgroup analysis | ||||||
Age of diagnosis | ||||||
< 50 years | 44,298 | 17,641 | 0.510 | 0.431 | 0.99 (0.72–1.35) | 0.98 |
Menopausal status | ||||||
Premenopausal | 44,298 | 12,134 | 0.510 | 0.503 | 1.20 (0.88–1.64) | 0.24 |
Family history | ||||||
1st degree relative with BC | 41,876 | 7,582 | 0.533 | 0.462 | 1.04 (0.72–1.51) | 0.83 |
Second BC | ||||||
Contralateral BC | 38,310 | 2,144 | 0.506 | 0.373 | 1.00 (0.48–2.10) | 0.99 |
Receptor status | ||||||
ER positive | 44,298 | 35,969 | 0.510 | 0.442 | 0.98 (0.80–1.21) | 0.88 |
ER negative | 44,298 | 9,343 | 0.510 | 0.503 | 1.21 (0.87–1.68) | 0.26 |
Triple negative | 44,298 | 4,017 | 0.510 | 0.448 | 1.26 (0.76–2.06) | 0.37 |
