Table 1 Number of individual rats that deteriorate on the day of the endpoint.
From: Body weight algorithm predicts humane endpoint in an intracranial rat glioma model
Endpoint | |
|---|---|
Body weight loss | 22/22* |
Deteriorated clinical score | 22/22* |
Species-specific behaviour | |
Decreased nest complexity | 3/9 |
Less Burrowing | 9/14* |
Motor related | |
Decreased distance | 10/14 |
Slower on balance-beam | 10/14* |
Shorter time on rotarod | 8/9 |
Social behaviour | |
Decreased total interaction (Duration) | 6/8 |
Decreased total interaction (Frequency) | 6/8 |
Telemetry | |
Increased heart rate (Light) | 4/7 |
Decreased heart rate(Dark) | 4/7 |
Decreased SDNN (Light) | 7/7* |
Decreased SDNN (Dark) | 6/7 |
Decreased activity (Light) | 5/7 |
Decreased activity (Dark) | 6/7 |
Increased body temperature (Light) | 4/7 |
Decreased body temperature (Dark) | 4/7 |
