Figure 2

Kaplan Meier plots for the combined genotypes of SNPs rs12150220 (NLRP1) and rs13334970 (SRL). X-axis: days from randomization, Y-axis: estimated probability of progression free survival (PFS). Log-rank test p-values are given for each KM plot. Individuals carrying at least one major allele for each of these two SNPs constituted the largest group, which was used as baseline in Cox proportional hazards modelling (continuous line). Individuals homozygous on the rare allele A for SRL rs13334970 and carrying at least one major allele A for NLRP1 rs12150220 - dotted line. Individuals homozygous on the rare allele T for NLRP1 rs12150220 – interrupted line. (a) APD – overall patients. (b) MAVERICC – overall patients. The combination validates in this subgroup. (c) TRIBE – overall patients. No validation in this subgroup. (d) The 3 cohorts combined – overall patients. (e) APD KRAS wt. (f) MAVERICC KRAS wt. (g) TRIBE KRAS wt. (h) The 3 cohorts combined – KRAS wt patients. There was validation for negative association between the individuals homozygous on the rare allele A for SRL rs13334970 and at least one major allele A for NLRP1 rs12150220 and PFS in both MAVERICC and TRIBE KRAS wt patients, with the association retaining significance when combining the 3 cohorts.