Table 1 Mean ± SD and statistical results (t-Student and least squares regression) of physiological, haematological, and urinary parameters in healthy and acute kidney injury secondary to sepsis/pyometra bitches.

From: Clinical and ultrasound variables for early diagnosis of septic acute kidney injury in bitches with pyometra

Parameter

Healthy patients

AKI patients

P-value

Regression coefficient

Probability ratio

Physical exam

HR (bpm)

108 ± 26.3

131 ± 39.5

0.0025*

0.28

1.32

fR (rpm)

21.5 ± 24.0

36.0 ± 31.0

0.0201

N/A

N/A

GCS

18.0 ± 0.00

18.0 ± 1.00

0.0396

N/A

N/A

Temperature (°C)

38.5 ± 0.77

38.8 ± 0.77

0.6253

N/A

N/A

SAP (mmHg)

115.8 ± 23.8

115 ± 32.5

0.8607

N/A

N/A

Hemogram

Haematocrit (%)

48.9 ± 3.50

41.3 ± 15.1

0.0005*

−2.96

0.07

Haemoglobin (g/dL)

17.1 ± 1.25

14.2 ± 5.40

0.0019*

−2.31

0.10

Erythrocytes (x106/uL)

6.96 ± 0.51

5.87 ± 2.17

0.0060*

−0.06

1.00

Leukocytes (x103/uL)

10.2 ± 3.39

20.8 ± 27.7

0.0090*

0.47

1.23

Neutrophils (x103/uL)

7.70 ± 3.07

15.9 ± 20.6

0.0239

N/A

N/A

Monocytes (x103/uL)

0.31 ± 0.28

0.79 ± 1.90

0.0239

N/A

N/A

Band cells (x103/uL)

0.00 ± 0.02

0.07 ± 0.73

0.0399

N/A

N/A

Lymphocytes (x103/uL)

1.78 ± 0.95

2.39 ± 0.25

0.1498

N/A

N/A

Eosinophils (x103/uL)

0.38 ± 0.20

0.19 ± 0.50

0.2252

N/A

N/A

MCV (fL)

70.1 ± 0.67

67.9 ± 5.72

0.2429

N/A

N/A

MCH (pg)

24.5 ± 0.25

24.4 ± 1.73

0.4636

N/A

N/A

MCHC (g/dL)

34.9 ± 0.12

35.1 ± 1.66

0.6404

N/A

N/A

Platelets (x103/uL)

323 ± 77.7

322 ± 203

0.8763

N/A

N/A

Basophils (x103/uL)

0.00 ± 0.00

0.00 ± 0.00

1.0000

N/A

N/A

Biochemical

Albumin (g/dL)

3.46 ± 0.37

0.39 ± 0.82

0.0002*

−3.57

0.03

Globulins (g/dL)

3.92 ± 1.30

5.80 ± 1.59

0.0004*

0.49

1.63

ALP (U/L)

53.0 ± 22.6

184 ± 144

0.0053*

0.23

1.00

ALT (U/L)

43.0 ± 8.67

23.00 ± 25.50

0.0233

N/A

N/A

Creatinine (mg/dL)

1.20 ± 0.10

1.00 ± 0.54

0.0423

N/A

N/A

Total Protein (g/dL)

7.58 ± 0.97

8.20 ± 1.52

0.1191

N/A

N/A

TBilirubin (mg/dL)

0.32 ± 0.23

0.20 ± 0.15

0.1265

N/A

N/A

UBilirubin (mg/dL)

0.06 ± 0.08

0.09 ± 0.07

0.1279

N/A

N/A

CBilirubin (mg/dL)

0.08 ± 0.03

0.09 ± 0.09

0.7240

N/A

N/A

Glycaemia (mg/dL)

88.5 ± 17.8

92.5 ± 21.8

0.5202

N/A

N/A

Urinalysis

UP/CR

0.06 ± 0.07

0.39 ± 0.82

0.0001*

9.80

3.68

Density

1.033 ± 0.01

1.020 ± 0.01

0.1720

N/A

N/A

Hemogasometry

CaHCO3 (mmol/L)

19.2 ± 1.37

18.1 ± 2.72

0.0064*

−0.19

0.88

PaO2 (mmHg)

97.2 ± 7.58

69.7 ± 53.2

0.0323

N/A

N/A

PaO2/FiO2

462 ± 36.1

331 ± 253

0.0323

N/A

N/A

PaCO2 (mmHg)

33.4 ± 3.97

29.9 ± 8.00

0.0429

N/A

N/A

pH

7.39 ± 0.03

7.39 ± 0.05

0.7702

N/A

N/A

  1. SD: standard deviation, AKI: Acute kidney injury, HR: Heart rate, bpm: beats per minute; fR: Respiratory rate, rpm: Respirations per minute; GCS: Glasgow coma scale, SAP: Systolic arterial pressure, MCV: Mean corpuscular volume, MCH: mean corpuscular haemoglobin, MCHC: mean corpuscular haemoglobin concentration, ALP: alkaline phosphatase, ALT: Alanine aminotransferase, TBilirubin: Total bilirubin, UBilirubin: Unconjugated bilirubin, CBilirubin: Conjugated bilirubin, UP/CR: urinary protein/creatinine ratio, CaHCO3: arterial bicarbonate concentration, PaO2: arterial partial pressure of oxygen, FiO2: Fraction inspired of oxygen, PaCO2 arterial partial pressure of carbon dioxide, N/A: Not applicable. *Considered statistically significant by t-Student test, (P ≤ 0.01).
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