Table 1 mRNA levels of γ-secretase components.

From: The impact of capsaicinoids on APP processing in Alzheimer’s disease in SH-SY5Y cells

 

APH1a

NCSTN

PSEN1

PSEN2

PSENEN

capsaicin

128 ± 67%

0.6077

132 ± 13%

0.0137*

128 ± 5%

0.0002***

137 ± 27%

0.1299

111 ± 11%

0.2637

natural compound

156 ± 19%

0.0055**

145 ± 18%

0.0119*

155 ± 19%

0.0073 **

153 ± 17%

0.0043 **

103 ± 3%

0.2783

dihydrocapsaicin

215 ± 30%

0.0012**

190 ± 18%

0.0002***

169 ± 23%

0.0048 **

156 ± 21%

0.0096 **

100 ± 14%

0.9905

  1. RT-PCR results for the single γ-secretase components including APH1a, NCSTN (nicastrin), PSEN1 (PS1), PSEN2 (PS2) and PSENEN (presenilin enhancer) in human neuroblastoma cells after incubation of capsaicinoids. Mean ± standard error of the mean are listed on the left row and statistical significance calculated by unpaired Student’s t test or ANOVA (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001) on the right row, respectively.
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