Figure 2

The effect of IS on regional NE (a), E levels (b) and NE turnover (c); n = 45. (a) Data are presented as the mean ± SD due to passed normality test (alpha=0.05). B1 – Anova – 0.0001 / F (DFn, DFd) = F (2, 42) = 11.83; Student t-test: ***CON vs 200 IS P = 0.0001; **100 IS vs 200 IS P = 0.0002. B2 – Anova – 0.0006 / F (DFn, DFd) = F (2, 42) = 9.074; Student t-test: **CON vs 100 IS P = 0.0068; **CON vs 200 IS P = 0.0017. All Controls Anova – 0.0001 / F (DFn, DFd) = F (4, 70) = 24.32. All 100 IS Anova – 0.0001 / F (DFn, DFd) = F (4, 70) = 19.92. All 200 IS Anova – 0.0001 / F (DFn, DFd) = F (4, 70) = 27.89. (b) Data are presented as a median (full range) due to unmeet normal distribution condition (alpha = 0.05). Data were analyzed using Kruskal-Wallis test. All Controls Kruskal-Wallis test – 0.0193 / Kruskal-Wallis statistic 7.897. All 100 IS Kruskal-Wallis test– 0.0025 / Kruskal-Wallis statistic 11.95. All 200 IS Kruskal-Wallis test – 0.0298 / Kruskal-Wallis statistic 7.024. (c) Data are presented as a median (full range) due to unmeet normal distribution condition (alpha=0.05). Data were analyzed using Kruskal-Wallis test. All Controls Kruskal-Wallis test – <0.001 / Kruskal-Wallis statistic 25.25. All 100 IS Kruskal-Wallis test– <0.0001 / Kruskal-Wallis statistic 17.94. All 200 IS Kruskal-Wallis test – 0.0003 / Kruskal-Wallis statistic 16.37. B1 – cerebellum; B2 – brainstem; B3 – cerebral cortex; B4 – hypothalamus; B5 – striatum with hippocampus; NE – norepinephrine; E – epinephrine; E/NE ratio – NE turnover; CON – control group; 100 IS – group receiving IS in the dose of 100 mg/kg b.w./day; 200 IS – group receiving IS in the dose of 200 mg/kg b.w./day.