Figure 1 | Scientific Reports

Figure 1

From: Crystal structures of Uso1 membrane tether reveal an alternative conformation in the globular head domain

Figure 1

Overall structure of yeast Uso1GHR. (a) A schematic diagram of the full length Uso1 protein. GHR, CC, and AD denote globular head region, coiled-coil region, and acidic domain, respectively. HR1 and HR2 are highly conserved regions in Uso1 and p115 proteins. GHRN and GHRC are the N- and C-terminal regions (residues 1–360 and 360–726) of GHR domain, respectively. The construct used for structure determination is shown in blue. (b) Overall structure of yeast Uso1GHR (Uso1_open), consisting of 12 armadillo (ARM) repeats. Each ARM repeat consists of 3 helices; H1 (green), H2 (blue), and H3 (yellow). HR1 and USO1 helix are denoted in brown and red, respectively. Additional regions 1 and 2 are shown in magenta. (c) Ribbon diagrams of Uso1GHR (Uso1_open and Uso1_closed). GHRN and GHRC are denoted by different colours. Additional regions 1 and 2 are shown in magenta. The positions of HR1 and HR2 are indicated by dotted circles.

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