Figure 7

Five different patients showing a patterns of AO-IRAF microstructure suggesting a redistribution and/or loss of RPE fluorophores. The white arrowheads denote a few locations where individual RPE cells are visible (RLAB-004 and RLAB-101). The yellow arrows mark the areas where the cone signature is seen in the AO-IRAF images with the corresponding area marked in the confocal AOSLO images. Cyan arrowhead points to an example area with highly reflective structure in the confocal image with AO-IRAF image showing absence of AF signal. In RLAB-102 the red arrow indicates an example area with no signal in either channel, potentially showing altered cone mosaic in confocal channel correlating with altered AF signal. Neither individual RPE cells nor cone signatures were seen in the AO-IRAF images of RLAB-0120 and RLAB-0168, despite well resolved cones in the confocal image and fine microstructural details visible in the AO-IRAF images.