Figure 1

Time-volume-curves. Time-volume curves of the left atrium and left ventricle in early-onset AF cases with TTNtv, early-onset AF without TTNtv and controls. All volumes are indexed to BSA. Shown as mean with error bars representing standard error of the mean. AF, atrial fibrillation; BSA, body surface area; LA, left atrium; LAbac, volume before atrial contraction; LAmax, maximum volume; LAmdv, mid-diastolic volume; LAmin, minimum volume; LV, left ventricle; TTNtv, titin-truncating variants.