Table 2 cMRI parameters.

From: Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis

 

AF with TTNtv

AF without TTNtv

Controls

P-value

P-value

Cardiac index, mL/min/m2

3856 (601)

3903 (618)

3668 (720)

0.436

0.330

Heart rate, bpm

72 (12)

66 (10)

62 (13)

0.018§

0.264

LA volumes, ml/m2

     

   LAmini

24 (7)

25 (5)

27 (8)

0.252

0.232

   LAmaxi

52 (12)

55 (10)

60 (11)

0.103

0.264

   LAmdvi

34 (8)

37 (8)

41 (10)

0.059

0.317

   LAbaci

35 (9)

40 (9)

44 (11)

0.025§

0.278

LA emptying volumes, ml/m2

     

   LA passive emptying volumei

18 (6)

18 (5)

19 (6)

0.705

0.625

   LA active emptying volumei

11 (4)

15 (5)

16 (4)

0.002§

0.530

   LA conduit volumei

25 (5)

26 (6)

25 (6)

0.779

0.432

   LA total emptying fraction

54 (9)

56 (6)

55 (6)

0.793

0.571

   LA passive emptying fraction

34 (6)

33 (7)

32 (9)

0.456

0.808

   LA active emptying fraction

32 (9)

38 (7)

37 (5)

0.059

0.817

   LA passive/active ratio

168 (2)

122 (2)

115 (2)

0.032§

0.739

LA LGE, %

8 (2)

5 (2)

3 (3)

<0.001§

0.064

LV parameters

     

   LV mass, g/m2

62 (11)

63 (9)

65 (12)

0.408

0.542

   LVEF, %

57 (4)

61 (4)

64 (5)

<0.001§

0.020§

   LVEDV, ml/m2

95 (17)

98 (10)

94 (15)

0.767

0.272

   LVESV, ml/m2

41 (7)

39 (5)

34 (8)

0.013§

0.033§

   LV stroke volume, ml/m2

53 (1)

59 (1)

59 (1)

0.174

0.980

   LVPFR, ml/s/m2

266 (59)

296 (79)

316 (74)

0.049

0.472

  1. Values are shown as mean (SD) unless otherwise stated. All volumes are indexed to BSA (marked with a subscript i). Individuals with complete volumetric measurements: AF with TTNtv; n = 14, AF without TTNtv; n = 15, controls; n = 17. Individuals with complete LA LGE measurements: AF with TTNtv; n = 17, AF without TTNtv; n = 17, controls; n = 13. AF, atrial fibrillation; bpm, beats per minute; BSA, body surface area; LA, left atrial; LAbac, LA volume before atrial contraction; LAmdv, LA mid-diastolic volume (volume after passive emptying but before mid-diastolic expansion); LA LGE, left atrial late gadolinium enhancement; LV, left ventricular; LVEF, LV ejection fraction; LVEDV, LV end-diastolic volume; LVESV, LV end-systolic volume; LVPFR, LV peak filling rate; SE, standard error; TTNtv, titin-truncating variant. Comparisons between AF patients with TTNtv and controls. Comparisons between AF patients without TTNtv and controls.
  2. §Statistically significant.