Table 2 The human ALK6 variant rs34970181_A was associated with NAFLD in a retrospective cohort study. Data from human carriers of rs34970181_A and matched non-carriers are presented. Matched characteristics are shown in the bottom section including age, BMI, sex, and race. Unmatched characteristics are shown in the top section. NAFLD status was determined by blinded physician chart review. Diabetes status was determined by ICD coding of the disease. Reported lab values are means of lifetime median values. Comparisons were performed using Fisher’s exact test for categorical data and Student’s t test for continuous variables.
From: The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease
Phenotype | rs34970181_A (n = 70) | Non-carrier (n = 140) | P-value |
|---|---|---|---|
NAFLD | 21.4% | 10.0% | 0.03 |
Diabetes | 13.8% | 10.1% | 0.49 |
Total Cholesterol (mg/dL) | 182 ± 6 | 181 ± 4 | 0.93 |
LDL (mg/dL) | 103 ± 5 | 103 ± 3 | 0.99 |
HDL (mg/dL) | 51 ± 3 | 53 ± 2 | 0.51 |
Triglycerides (mg/dL) | 146 ± 5 | 129 ± 6 | 0.07 |
ALT (U/L) | 25 ± 2 | 28 ± 4 | 0.53 |
AST (U/L) | 27 ± 2 | 27 ± 1 | 0.72 |
Age (years) | 66 ± 0.3 | 66 ± 0.1 | 0.95 |
BMI (kg/m2) | 28.2 ± 0.5 | 28.4 ± 0.7 | 0.89 |
Female | 38.6% | 37.5% | 0.76 |
White | 93.1% | 93.1% | 1 |
