Figure 1
From: LTP of inhibition at PV interneuron output synapses requires developmental BMP signaling
AP-firing properties and passive membrane properties of PV-INs are largely unchanged in BMPR1a/1b (c)DKO mice. (A) AP-firing of a PV-IN in a control mouse of age P22, in response to 1-s current steps to −200, −100 and +200 pA. (B) Instantaneous AP frequency (top) and plot of AP-frequency as a function of injected current (bottom). (C) Exponential fit (dashed blue line) to the membrane potential (Vm) relaxation caused by a −100 pA current injection, to determine the membrane time constant (τm; top), and plot of the steady-state Vm value as a function of the injected current to determine membrane resistance (slope = 130 MΩ in this example). The data in (A–C) are from the same recording. (D–F) Same as (A–C), but for a recording of a PV-IN in a BMPR1a/1b (c)DKO mouse of age P19. (G) Individual - and average data of the maximal AP firing frequency in control mice (left, black data points) and in BMPR1a/1b (c)DKO mice (right, red data points). (H) Individual - and average data for maximal adaptation (left), and for the firing rate gain (right). The latter was calculated as the slope in the plots of AP-firing versus injected current (B,E, bottom). (I) Individual - and average data for membrane resistance (left) and membrane time constant (right). For the number of recordings (n) and number of mice (N), and the statistical tests used, see Results.
