Figure 2
From: LTP of inhibition at PV interneuron output synapses requires developmental BMP signaling
Knock-out of BMP-type1 receptors in PV-INs leads to an increased release probability, but does not affect baseline synaptic transmission at PV-IN output synapses. (A) APs evoked by brief current injections in PV-INs (Vm traces on top), and the resulting IPSCs in a postsynaptic principal neuron of layer 4 (middle). The bottom panels show peak-normalized IPSCs averaged from a larger number of stimulations (n = 40–60). From left to right, example paired recording from a control mouse at P23, from a BMPR1a/1b (c)DKO mouse at P21, and from a BMPR1b sKO at P22. (B) Individual - and average values of unitary IPSC amplitudes recorded in paired recordings in control mice (left); in BMPR1a/1b (c)DKO mice (middle) and in BMPR1b sKO mice (right). A Kruskal-Wallis test did not find a significant difference between the groups (see Results). (C) Individual - and average data for paired-pulse ratio (PPR) in a subset of recordings in which paired stimulation was applied, for the same genotypes as in (B). (D) Individual- and average values of the IPSC variance - mean ratio of the IPSC peak amplitudes, in control mice (left) and in BMPR1a/1b (c)DKO mice (right). In panels (B–D), the number of recordings (“n”) is indicated on the x-axis; for the number of animals (“N”) see Results. For statistical tests and p-values, see Results. **p < 0.01; n.s., not significant.
