Figure 1

Pre-treatment GDF-15 and FGF-21 serum levels are associated with disease severity. Histograms representing the basal (before treatment) serum levels (mean and SEM) of GDF-15, FGF-21 and creatine kinase (CK) in patients from Group 1 (G1), those patients from Group 1 with the early onset and the most severe phenotype (G1-EO) and patients in Group 2 (G2). Dotted lines represent control values.