Figure 5
From: Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression
Nuclear morphology changes correlated with mitochondrial fractal dimension during VIC osteogenic differentiation. (a) Average nuclear area in pixels for VIC cultures for days 1 through 28 under quiescent or osteogenic conditions on compliant or stiff substrates. (b) Optical redox ratio correlated with average nuclear area. (c) Fractal dimension correlated with the average nuclear area. (d) Nuclear aspect ratio for VIC cultures for days 1 through 28 under quiescent or osteogenic conditions on compliant or stiff substrates. (e) Optical redox ratio correlated with nuclear aspect ratio. (f) Fractal dimension correlated with the nuclear aspect ratio. N = 5–6, *p < 0.05. Pearson’s correlation coefficient is denoted as (R).
