Figure 1

Summary of overall survival (a) and progression-free survival (b) in patients with locally advanced/MBC, by site of lesions at baseline (pooled population). (a) Patients randomized to eribulin had a nominally significant difference in overall survival compared with control in the overall pooled population. Patients with bone, liver, lymph node and chest wall/breast/skin metastases had a nominally significant difference in overall survival with eribulin compared with TPC/capecitabine. (b) Overall, patients treated with eribulin had a nominally significant difference compared with control in progression-free survival. Assessment by baseline lesion location, revealed only patients with baseline bone metastases randomized to eribulin had a nominally significant difference in progression-free survival compared with TPC/capecitabine. Control includes TPC and capecitabine; HR values and 2-sided 95% CIs were computed using Cox models with treatment as a covariate and stratified by study, region, prior capecitabine use, and HER2/neu status; nominal P values were based on log-rank tests and stratified as noted above. Medians were based on survival curves adjusted by study. CI, confidence interval; HR, hazard ratio; MBC, metastatic breast cancer; TPC, treatment of physician’s choice.