Table 3 Correlation between regional gray matter volume and mood and cognition in T2DM subjects.

From: Regional Brain Gray Matter Changes in Patients with Type 2 Diabetes Mellitus

Measures	Brain Regions	Correlation Coefficient	P- values	Voxel Count
Anxiety (BAI, n = 34)	Left Caudate	−0.504	0.003	1421
	Right Caudate	−0.470	0.007	294
	Left Hippocampus	−0.545	0.001	802
	Right Hippocampus	−0.582	<0.001	1723
	Left Putamen	−0.530	0.002	578
	Right Putamen	−0.499	0.004	110
	Left Thalamus	−0.485	0.005	350
	Right Thalamus	−0.488	0.005	80
	Left Basal Forebrain	−0.532	0.002	249
	Right Anterior Cingulate	−0.477	0.006	156
	Right Mid Cingulate	−0.485	0.005	116
	Left Posterior Cingulate	−0.494	0.004	368
	Left Anterior Insula	−0.525	0.002	788
	Right Anterior Insula	−0.556	0.001	2729
	Left Posterior Insula	−0.508	0.003	224
	Right Posterior Insula	−0.509	0.003	703
	Left Lingual Gyrus	−0.542	0.001	539
	Right Lingual Gyrus	−0.566	0.001	1205
	Left Parahippocampus	−0.510	0.003	148
	Right Amygdala	−0.485	0.005	270
	Left Inferior Temporal	−0.530	0.002	340
	Right Inferior Temporal	−0.532	0.002	717
	Left Mid Temporal	−0.503	0.003	814
	Right Mid Temporal	−0.533	0.002	639
	Left Superior Temporal	−0.504	0.003	208
	Right Superior Temporal	−0.503	0.003	366
	Left Prefrontal	−0.503	0.003	76
	Right Ventral Medial Prefrontal	−0.485	0.005	96
	Right Inferior Frontal	−0.522	0.002	125
	Left Mid Frontal	−0.518	0.002	157
	Right Mid Frontal	−0.552	0.001	232
	Left Superior Frontal	−0.527	0.002	725
	Left Mid Occipital	−0.493	0.004	87
	Right Mid Occipital	−0.583	<0.001	414
	Left Superior Occipital	−0.588	<0.001	840
	Right Superior Occipital	−0.563	0.001	801
	Left Superior Parietal	−0.555	0.001	560
	Right Superior Parietal	−0.634	<0.001	1343
	Left Precentral Gyrus	−0.495	0.004	82
	Left Postcentral Gyrus	−0.558	0.001	505
Depression (BDI-II, n = 32)	Left Prefrontal	−0.548	0.002	85
	Right Hippocampus	−0.533	0.002	947
	Left Thalamus	−0.483	0.007	114
	Right Parahippocampus	−0.558	0.001	794
	Right Inferior Frontal	−0.507	0.004	70
	Left Mid Temporal	−0.494	0.006	48
	Right Mid Temporal	−0.477	0.008	83
	Left Superior Temporal	−0.553	0.002	286
	Right Inferior Occipital	−0.514	0.004	93
	Right Mid Occipital	−0.529	0.003	151
	Left Superior Occipital	−0.489	0.006	63
Cognition (MoCA, n = 34)	Left Amygdala	0.517	0.002	849
	Right Amygdala	0.535	0.002	861
	Left Anterior Cingulate	0.586	<0.001	3407
	Right Anterior Cingulate	0.547	0.001	3371
	Left Posterior Cingulate	0.495	0.004	817
	Left Mid Cingulate	0.499	0.004	298
	Left Hippocampus	0.543	0.001	1450
	Right Hippocampus	0.598	<0.001	1623
	Left Anterior Insula	0.486	0.005	136
	Left Posterior Insula	0.519	0.002	609
	Right Posterior Insula	0.545	0.001	978
	Prefrontal Cortices	0.559	0.001	1518
	Right Putamen	0.482	0.005	103
	Right Lingual Gyrus	0.557	0.001	1068
	Left Parahippocampus	0.484	0.005	325
	Right Parahippocampus	0.491	0.004	499
	Left Cerebellar Cortices	0.482	0.005	153
	Right Cerebellar Cortices	0.465	0.007	83
	Left Mid Frontal	0.506	0.003	846
	Right Mid Frontal	0.586	<0.001	638
	Left Superior Frontal	0.548	0.001	2585
	Right Superior Frontal	0.550	0.001	1630
	Left Superior Parietal	0.594	<0.001	1177
	Right Superior Parietal	0.595	<0.001	1507
	Right Inferior Temporal	0.607	<0.001	1186
	Left Mid Temporal	0.565	0.001	2397
	Right Mid Temporal	0.483	0.005	119
	Right Superior Temporal	0.504	0.003	876
	Left Inferior Occipital	0.559	0.001	672
	Left Mid Occipital	0.521	0.002	155
	Right Precentral Gyrus	0.534	0.002	1129
	Left Postcentral Gyrus	0.618	<0.001	2219
	Right Postcentral Gyrus	0.590	<0.001	1147

BAI = Beck Anxiety Inventory; BDI-II = Beck Depression Inventory II; MoCA = Montreal Cognitive Assessment.

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Table 3 Correlation between regional gray matter volume and mood and cognition in T2DM subjects.

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