Figure 2 | Scientific Reports

Figure 2

From: Analyzing microglial-associated Aβ in Alzheimer’s disease transgenic mice with a novel mid-domain Aβ-antibody

Figure 2

Binding of antibody ab338 to spot-synthesized Aβ-peptides relates to β-turn score in Aβ. (A) The amino acid sequences of the spot-synthesized Aβ-peptides with amino acid numbers in the Aβ-domain. (B) Antibody ab338 binding to Aβ-sequences spot-synthesized to membrane (top) and a graphical illustration of the optical density as a measure of ab338 preference for the spot-synthesized peptides. A high signal from Aβ-peptide sequences starting from amino acid 19–28 and ending at 24–33 (25–34) corresponded to a (C) high β-turn score of Aβ-peptides calculated by Tango. Illustration of Aβ-fibrils with β-sheets of β-strands and β-turns formed by Aβ-peptide. The drawing is based on the Aβ40-fibril structural model of sequences and are presented as suggested by Petkova et al. (2002), PNAS54.

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