Table 1 Frequency of genotypes associated with selected FCN1 single nucleotide gene polymorphisms.

From: Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults

Polymorphism

Genotype

Group

C

AML

AML-A

AML-B

AML-C

AML-D

-542 G > A

G/G

95 (37)

77 (49)1

19 (46.3)

26 (44.1)

5 (83.3)

27 (52.9)2

(rs10120023)

G/A

125 (48.6)

54 (34.4)

13 (31.7)

24 (40.7)

1 (16.7)

16 (31.4)

A/A

37 (14.4)

26 (16.6)

9 (22)

9 (15.3)

0

8 (15.7)

-144 C > A

C/C

98 (38.1)

64 (48.8)

10 (24.4)

26 (44.1)

1 (16.7)

27 (52.9)

(rs10117466)

C/A

123 (47.9)

72 (45.9)

22 (53.7)

25 (42.4)

3 (50)

22 (43.1)

A/A

36 (14)

21 (13.4)

9 (22)3

8 (13.6)

2 (33.3)

2 (3.9)

+ 6,658 G > A

G/G

256 (99.6)

156 (99.4)

41 (100)

58 (98.3)

6 (100)

51 (100)

(rs148649884)

G/A

1 (0.4)

1 (0.6)

0

1 (1.7)

0

0

A/A

0

0

0

0

0

0

  1. Percentages are shown in parentheses. Allele distributions were in accordance with Hardy–Weinberg equlibrium, with an exception for − 542 G > A polymorphism in AML group where G/G homozygosity was more common than predicted.
  2. C: controls; AML-A: patients who experienced infections with proven bacteremia and/or fungaemia; AML-B: patients who experienced infections with no bacteremia; AML-C: patients who experienced febrile neutropenia; AML-D: patients who experienced none of afore-mentioned complications within 4 weeks of hospital stay.
  3. 1p = 0.018, OR = 1.6, 95% CI (1.1–2.45) (vs. C) [multiple logistic regression, dominant model: p = 0.004, OR = 2.95, 95% CI (1.41–6.16)].
  4. 2p = 0.041, OR = 1.9, 95% CI (1.05–3.51) (vs. C).
  5. 3p = 0.01, OR = 6.9, 95% CI (1.4–33.98) (vs. AML-D).
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