Table 4 Ficolins and mannose-binding lectin as potential disease markers (data from ROC analysis).
From: Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults
Protein | AML versus | Curve area | 95% CI | Significance | Cut-off (μg/ml) | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|
Ficolin-1 | C | 0.866 | 0.825–0.907 | p < 0.0001 | 0.55 | 70.7 | 94.9 |
MM | 0.767 | 0.713–0.821 | p < 0.0001 | 0.325 | 56.7 | 93.1 | |
LYMPH | 0.695 | 0.633–0.757 | p < 0.0001 | 0.27 | 51.6 | 90.5 | |
MM + LYMPH | 0.739 | 0.685–0.794 | p < 0.0001 | 0.27 | 51.6 | 94.1 | |
Ficolin-2 | C | 0.688 | 0.635–0.742 | p < 0.0001 | 5.225 | 43 | 83.9 |
MM | 0.775 | 0.726–0.825 | p < 0.0001 | 3.378 | 75.6 | 66.7 | |
LYMPH | 0.838 | 0.789–0.884 | p < 0.0001 | 3.288 | 78.2 | 78.3 | |
MM + LYMPH | 0.799 | 0.756–0.842 | p < 0.0001 | 3.288 | 78.2 | 69.5 | |
Ficolin-3 | C | 0.83 | 0.789–0.871 | p < 0.0001 | 24.4 | 73.9 | 80.3 |
MM | 0.806 | 0.76–0.853 | p < 0.0001 | 27.7 | 68.2 | 82.2 | |
LYMPH | 0.824 | 0.776–0.873 | p < 0.0001 | 26.4 | 70.1 | 82.8 | |
MM + LYMPH | 0.813 | 0.771–0.856 | p < 0.0001 | 27.7 | 68.2 | 82.7 | |
MBL | C | 0.593 | 0.532–0.654 | p = 0.015 | 1.873 | 44 | 81.5 |
MM | 0.558 | 0.495–0.62 | p = 0.065 | 2.964 | 27.4 | 90.9 | |
LYMPH | 0.559 | 0.491–0.627 | p = 0.096 | 2.912 | 27.4 | 92.2 | |
MM + LYMPH | 0.558 | 0.499–0.617 | p = 0.041 | 2.964 | 27.4 | 91.4 |
