Table 1 HpHtrA interaction with Zn++.

From: A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding

Protein

Response amplitude

S/Na

Kdb (µM ± SD)

HpHtrA wt

4.3

6.3

23 ± 12

HpHtrA S164A

3.6

6.0

55 ± 34

HpHtrA D165A

3.6

3.9

n.d.c

HpHtrA S166A

3.9

3.8

n.d

HpHtrA D168A

2.7

3.5

n.d

  1. aS/N, signal to noise ratio; bKd, dissociation constant; cn.d., not determined.
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