Figure 2 | Scientific Reports

Figure 2

From: Hepatic regeneration following radiation-induced liver injury is associated with increased hepatobiliary secretion measured by PET in Göttingen minipigs

Figure 2

PET/CT images and time activity curves from dynamic [11C]CSar scans in a control pig (Pig C3; a–c) and an irradiated pig with lobular inflammation and impaired hepatobiliary function (Pig R4; d–f). The PET/CT images are coronal and show average concentration recorded 7.5–8.5 min (a, d) and 37.5–42.5 min (b,e) following bolus injection of 78 MBq [11C]CSar. Panels (c,f) display the time course of [11C]CSar concentration in arterial blood (red), liver tissue (black), and the common hepatic duct (CHD), divided by 50 (green). In both pigs, [11C]CSar is rapidly cleared from blood and accumulated in the liver tissue. In the control pig, [11C]CSar is almost completely cleared from the liver and excreted into the CHD at 37.5–42.5 min, while high concentrations of [11C]CSar still remain in the liver of the irradiated pig and is excreted at a reduced rate.

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