Figure 6

Kinetic two-tissue compartmental model of transport of [11C]CSar from blood to bile. K1: unidirectional clearance from blood to hepatocytes (mL blood/min/mL liver tissue); k2: rate constant for backflux from hepatocytes to blood (/min); k3: rate constant for secretion from hepatocytes to intrahepatic bile ducts (/min); k5: rate constant for bile flow out of the liver (/min). Liver-VOI liver volume-of-interest (VOI).