Figure 6 | Scientific Reports

Figure 6

From: Role of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme

Figure 6

(A) Solid surface top view of the arachidonic acid binding pocket (site 1) and allosteric site (site 2) of COX-2 in association with 1 (pink). For site 1, the yellow part represents hydrophobic region whereas green is the hydrophilic region. For simplicity, the hydrophobic and hydrophilic regions of site 2 are not differentiated. (B) 2D view of red boxed part of the binding site showing interaction of 1 with amino acids.

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