Scheme 1 | Scientific Reports

Scheme 1

From: Role of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme

Scheme 1

Reaction conditions: (i) K2CO3, CuO, iso-amyl alcohol, 150 °C, reflux, 36 h; (ii) NaH, DMF, 40 °C, 4 h; (iii) Piperidine, CHCl3, MWI, 120 °C, 20 min; (iv) NaH, ACN, 70 °C, 24 h; (v) DMF, MWI, 150 °C, 1 h; (vi) CH3I, K2CO3, DMF, 40 °C, 6 h; (vii) 145 °C, 15 min; (viii) K2CO3, DMF, 40 °C, 24 h; (ix) Anhydrous AlCl3, dry DCM, N2 atm, 2 h.

Back to article page