Table 2 IC50 (μM) of the compounds for COX-2 and COX-1.
Compound | IC50 (μM)* | SI (IC50(COX-1)/IC50 (COX-2) | |
|---|---|---|---|
wt COX-2 | COX-1 | ||
1 | 0.06 | 60.00 | 1,000 |
2 | 0.10 | 40.00 | 400 |
3 | 10.00 | > 100 | > 10 |
4 | 2.15 | 33.00 | 15 |
5 | 0.15 | 53.00 | 350 |
6 | 0.35 | 60.00 | 160 |
7 | 22.00 | > 100 | > 4.5 |
8 | 0.12 | 48.00 | 400 |
9 | 0.23 | 52.00 | 250 |
10 | 12.00 | > 100 | > 8 |
13d | 48.50 | > 100 | > 2 |
15d | 23.48 | > 100 | > 4 |
Indomethacin | 0.08 | 0.96 | 12 |
Celecoxib | 0.04 | 15 | 375 |
