Table 3 PK parameters of compound 1.

From: Role of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme

Parameter

Animal

Mean

1

2

3

T1/2 (min)

671.3

417.8

520.9

536.7

Tmax (min)

30

15

30

25

Cmax (μM)

3.15

2.86

2.6

3.15

AUC(0–1440 min)

1,282

1,179.9

1,214

1,225.4

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