Table 1 Maternal arterial acid–base and metabolic status.

From: Maternal and fetal cardiovascular and metabolic effects of intra-operative uterine handling under general anesthesia during pregnancy in sheep

Variable

Baseline

Uterine handling

Recovery

P value

( −30 min)

(0 min)

(15 min)

(30 min)

(60 min)

pH

7.40 ± 0.02

7.40 ± 0.02

7.39 ± 0.02

7.37 ± 0.02*

7.37 ± 0.02*

0.009

PaCO2 (mmHg)

51.6 ± 3.2

53.9 ± 4.2

57.4 ± 3.6*

59.3 ± 3.9*

59.0 ± 3.9*

< 0.001

PaO2 (mmHg)

202 ± 23

182 ± 20

168 ± 21

178 ± 25

174 ± 22

0.60

Oxyhemoglobin saturation (%)

102 ± 1

102 ± 1

102 ± 1

102 ± 1

102 ± 1

0.90

Arterial base excess (mmol l−1)

5.7 ± 1.6

6.3 ± 1.1

5.3 ± 0.9

6.0 ± 1.0

5.4 ± 1.1

0.70

Bicarbonate (mEq L−1)

31.7 ± 1.5

32.4 ± 1.3

32.4 ± 1.3

32.3 ± 1.2

31.4 ± 1.1

0.57

Lactate (mmol l−1)

0.7 ± 0.1

0.6 ± 0.1

0.6 ± 0.1

0.6 ± 0.1

0.6 ± 0.1

0.09

Hemoglobin (g d l−1)

8.9 ± 0.6

9.0 ± 0.5

9.1 ± 0.5

9.6 ± 0.3

9.7 ± 0.4*

0.04

Hematocrit (%)

24 ± 1

24 ± 1

25 ± 1

28 ± 1*

0.04

 
  1. Values represent mean ± SEM for n = 9 of maternal femoral arterial blood samples at the start (“− 30”) and end (“0”) of the baseline period; the midpoint (“15”) and end (“30”) of the period of uterine handling and the end of the recovery period (“60”). Significant differences are: *P < 0.05, for each timepoint when compared to timepoint “− 30”, assessed using a repeated-measures (RM) one-way ANOVA with post hoc Bonferroni test. The P value quoted in the final column is the overall significance of the RM ANOVA with Glasshouse–Geisser correction for the effect of time.
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