Figure 7
(a) Bar chart shows the number of genes correlated with lncRNAs specific to each clinical phenotypes. Red: upregulated mRNAs; green: downregulated mRNAs. (b) Pathways of genes correlated with upregulated lncRNAs specific to tumor grade are mainly related to DNA repair, cell cycle, p53 signaling pathways, viral infection and cellular senescence. (c) Pathways of genes correlated with downregulated lncRNAs specific to tumor grade are mainly related to fatty acid metabolism, glucose metabolism, drug metabolism and COP1-dependent retrograde traffic. (d) Pathways of genes correlated with downregulated lncRNAs specific to tumor invasion are mainly related to cellular response to metal ions. (e) Functional annotation shows that genes correlated with downregulated lncRNAs specific to tumor capsule are mainly involved in serine-type peptidase activity.
