Figure 3

SIV infection-related shifts in the colonic mucosa-associated microbiome at phylum lower taxonomic levels and microbial diversity. (A) and (B), Relative abundance of bacteria among the phyla Bacteroidetes (A) and Firmicutes (B) before infection, at the time of mucosal viral load peak, and in the chronic phase of SIV infection. Values correspond to the frequency within the total bacteria detected within each animal. (C) Shannon diversity index and Simpson diversity index were calculated for each animal. Mucosal peak viral load was observed on day 7 (black symbols) or day 14 after infection (grey symbols). The chronic phase was analyzed on day 49 after infection. Horizontal lines indicate mean values + /− standard deviations. *P < 0.05, **P < 0.01. VL viral load.