Figure 5 | Scientific Reports

Figure 5

From: The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4+ T cell depletion and enterocyte damage

Figure 5

SIV infection-related impact on enterocyte damage in the colon. (A) Serum concentrations of I-FABP, a sensitive biomarker for enterocyte damage, and the microbial translocation biomarker LBP before infection and on days 14 and 49 after SIV infection (acute and chronic stage of infection). Mucosal peak viral load was observed on day 7 (black symbols) or day 14 after infection (grey symbols). The chronic phase was analyzed on day 49 after infection. (B) Correlations of abundances of Bacteroidetes with initial SIV infection-associated changes in I-FABP and LBP serum levels. Values, depicted as percent change in I-FABP or LBP, were calculated for each animal as change between pre-infection levels and those at the time of mucosal peak viral load. *P < 0.05.

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