Table 3 Exonic mitochondrial SNPs associated with phenotypic traits and PCs.

From: Investigating the influence of mtDNA and nuclear encoded mitochondrial variants on high intensity interval training outcomes

Trait

CHR

SNP

Allele

Gene

Consequence

Model

GenBank MAF

MAF

SE (95% CI)

P-value*

FDR

Effect size (beta)

Δ-LT

MT

rs2000975

G

ATP6

Missense

ADD

0.019

0.032

11.24 (− 48.2 to − 4.2)

0.023

0.39

− 26.19

MT

rs2857284

C

ND4

Synonymous

ADD

0.021

0.032

11.24 (− 48.2 to − 4.2)

0.023

0.39

− 26.19

MT

rs193302956

T

ND5

Synonymous

ADD

0.12

0.081

7.25 (− 29 to − 0.5)

0.046

0.49

− 14.75

MT

rs193302985

A

CYB

Synonymous

ADD

0.044

0.113

6.08 (− 29 to − 5.2)

0.0067

0.28

− 17.10

PC3

MT

rs285728

C

ND4

Synonymous

ADD

0.021

0.032

0.72 (0.17 – 3.0)

0.032

0.54

1.57

MT

rs2000975

G

ATP6

Missense

ADD

0.019

0.032

0.72 (0.17 – 3.0)

0.032

0.54

1.57

PC4

MT

rs2853493

G

ND4

Synonymous

ADD

0.28

0.258

0.25 (− 1.0 to − 0.03)

0.041

0.69

− 0.53

MT

rs2853498

G

tRNALeu

− 

ADD

0.23

0.258

0.25 (− 1.0 to − 0.03)

0.041

0.69

− 0.53

MT

rs2853499

A

ND5

Synonymous

ADD

0.28

0.258

0.25 (− 1.0 to − 0.03)

0.041

0.69

− 0.53

  1. CHR chromosome #, SNP single nucleotide polymorphism, MAF minor allele frequency, SE standard error, CI confidence interval, FDR false discovery rate, Δ delta change, ADD additive model
  2. *P-value adjusted for age.