Table 5 Top associated targeted metabolites in the DIALONG study.

From: Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

 

Mean (SD)

 

Metabolite

NP

RP

p valuea

p valueb

Glycine [μmol/L]1

314.4 (62.2)

274.6 (45.8)

6.7e−03

8.7e−03

Serine [μmol/L]1

127.1 (26.7)

112.4 (28.3)

0.02

0.03

Phenylalanine [μmol/L]1

62.6 (7.2)

58.0 (7.7)

0.03

0.04

Tot. thiamine* [nmol/L]2

10.5 (6.4)

15.1 (12.2)

0.03

0.04

  1. Data were winsorized before analyses, and statistical tests performed on log2-transformed data.
  2. NP non-progressors, RP rapid progressors. nNP = 25, nRP = 27.
  3. Linear regression models: Pa (adjusted for sex, age), Pb (adjusted for sex, age, HbA1c).
  4. 1Bevital GC–MS/MS, 2Bevital LC–MS/MS.
  5. *Tot. thiamine is calculated as total of thiamine monophosphate and thiamine.
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